منابع مشابه
Sensing danger.
CRISPR-Cas loci encode for an adaptive immune system in prokaryotes that provides defense against viruses (1) and plasmids (2) that infect these organisms. CRISPR loci contain a series of repetitive sequences intercalated with short sequences derived from invading viruses and plasmids (3–5). These short sequences, called spacers, are acquired from the invader upon infection during an “immunizat...
متن کاملSensing Danger: Innate Immunology for Intrusion Detection
The immune system provides an ideal metaphor for anomaly detection in general and computer security in particular. Based on this idea, artificial immune systems have been used for a number of years for intrusion detection, unfortunately so far with little success. However, these previous systems were largely based on immunological theory from the 1970s and 1980s and over the last decade our und...
متن کاملThe Danger Signal S100B Integrates Pathogen– and Danger–Sensing Pathways to Restrain Inflammation
Humans inhale hundreds of Aspergillus conidia without adverse consequences. Powerful protective mechanisms may ensure prompt control of the pathogen and inflammation. Here we reveal a previously unknown mechanism by which the danger molecule S100B integrates pathogen- and danger-sensing pathways to restrain inflammation. Upon forming complexes with TLR2 ligands, S100B inhibited TLR2 via RAGE, t...
متن کاملSensing danger--Hsp72 and HMGB1 as candidate signals.
Molecules that behave as danger signals are produced when the body is perceived to be under attack, and they alert the immune system to the problem. The immune system can then mount an appropriate response. Two molecules that have received attention as potential danger signals are heat shock protein 72 (Hsp72) and high mobility group box 1 (HMGB1), which are intracellular proteins but are relea...
متن کاملFicolins: innate immune recognition proteins for danger sensing
Las ficolinas son proteínas de defensa que forman oligómeros a partir de tallos homólogos al colágeno y dominios semejantes a fibrinógeno. Son capaces de sentir señales de peligro tales como patrones moleculares asociados patógenos o a células apoptóticas. En el hombre, las ficolinas L y H se han caracterizado en el suero, mientras que la ficolina M es secretada por células monocíticas. Al igua...
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ژورنال
عنوان ژورنال: Journal of Molecular Biology
سال: 2015
ISSN: 0022-2836
DOI: 10.1016/j.jmb.2015.09.018